Estimation of relative potency using parallel line analysis

Estimation of relative potency in a 4-point, parallel line assay

For inhaled asthma medications, the current EMA guideline requires equivalence in respect of efficacy to be demonstrated also through a comparison between drugs in terms of relative potency. Differently from the more common comparison of the magnitude of responses observed following administration of different products, the doseresponse relationship is taken into account by this approach. In th...

Relative Potency Estimation in Parallel-Line Assays - Method Comparison and Some Extensions

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analysis of ruin probability for insurance companies using markov chain

در این پایان نامه نشان داده ایم که چگونه می توان مدل ریسک بیمه ای اسپیرر اندرسون را به کمک زنجیره های مارکوف تعریف کرد. سپس به کمک روش های آنالیز ماتریسی احتمال برشکستگی ، میزان مازاد در هنگام برشکستگی و میزان کسری بودجه در زمان وقوع برشکستگی را محاسبه کرده ایم. هدف ما در این پایان نامه بسیار محاسباتی و کاربردی تر از روش های است که در گذشته برای محاسبه این احتمال ارائه شده است. در ابتدا ما نشا...

Relative Potency Estimation in Direct Bioassay with Measurement Errors*

Relative potency estimation for synthetic petroleum skin carcinogens.

A procedure for quantitative analysis of skin carcinogenesis data, for the purpose of establishing carcinogenic potency, has been applied to observations obtained from C3H mice exposed continuously to synthetic and natural petroleums. The importance of total polynuclear aromatic (PNA) content to the skin carcinogenic activity of the crude materials was also examined. Of three synthetic petroleu...